Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | serotonin signalling activates the enzyme | Caenorhabditis elegans |
Cloned (Comment) | Organism |
---|---|
- |
Drosophila melanogaster |
- |
Mammalia |
- |
Arabidopsis thaliana |
- |
Caenorhabditis elegans |
expression of the isolated catalytic subunit of isozyme alpha shows 60% of maximal wild-type full length enzyme activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of the second glycine in the binding sequence motif GXGXXG of the ATP-binding site to aspartate or alanine renders the mutant enzymes catalytically inactive | Mammalia |
additional information | mutation of the second glycine in the binding sequence motif GXGXXG of the ATP-binding site to aspartate or alanine renders the mutant enzymes catalytically inactive | Homo sapiens |
additional information | the ATP binding sequence of isozyme DGK2in strain rdgA contains the mutant GXDXXG motif leading to rapid retinal degeneration after birth | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Drosophila melanogaster | 5829 | - |
cytosol | - |
Mammalia | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Arabidopsis thaliana | 5829 | - |
cytosol | - |
Caenorhabditis elegans | 5829 | - |
membrane | - |
Drosophila melanogaster | 16020 | - |
membrane | - |
Arabidopsis thaliana | 16020 | - |
membrane | - |
Caenorhabditis elegans | 16020 | - |
additional information | subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols | Drosophila melanogaster | - |
- |
additional information | subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols | Mammalia | - |
- |
additional information | subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols | Homo sapiens | - |
- |
additional information | subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols | Arabidopsis thaliana | - |
- |
additional information | subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols | Caenorhabditis elegans | - |
- |
perinuclear space | - |
Mammalia | - |
- |
perinuclear space | - |
Homo sapiens | - |
- |
plasma membrane | isozyme alpha | Mammalia | 5886 | - |
plasma membrane | isozyme alpha | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Drosophila melanogaster | |
Mg2+ | - |
Mammalia | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Arabidopsis thaliana | |
Mg2+ | - |
Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | Drosophila melanogaster | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | Mammalia | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | Homo sapiens | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | Arabidopsis thaliana | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | Caenorhabditis elegans | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid, isozyme dgk-1 regulates diacylglycerol signalling required for acetylcholine release | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
additional information | Mammalia | complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | ? | - |
? | |
additional information | Drosophila melanogaster | complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | ? | - |
? | |
additional information | Arabidopsis thaliana | complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | ? | - |
? | |
additional information | Caenorhabditis elegans | complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | ? | - |
? | |
additional information | Homo sapiens | the isozyme zeta interacts with phosphoinositol phosphate 5-kinase activating it via phosphatidic acid, isozyme theta associates with RhoA, complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Caenorhabditis elegans | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
9 different isozymes divided into 5 subtypes, alternative splicing of isozymes | - |
Mammalia | - |
9 different isozymes divided into 5 subtypes, alternative splicing of isozymes | - |
no activity in Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | - |
Mammalia | - |
T-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | - |
Drosophila melanogaster | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | i.e. phosphatidic acid | ? | |
ATP + 1,2-diacylglycerol | - |
Mammalia | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | i.e. phosphatidic acid | ? | |
ATP + 1,2-diacylglycerol | - |
Homo sapiens | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | i.e. phosphatidic acid | ? | |
ATP + 1,2-diacylglycerol | - |
Arabidopsis thaliana | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | i.e. phosphatidic acid | ? | |
ATP + 1,2-diacylglycerol | - |
Caenorhabditis elegans | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | i.e. phosphatidic acid | ? | |
ATP + 1,2-diacylglycerol | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | Drosophila melanogaster | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | Mammalia | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | Homo sapiens | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid | Arabidopsis thaliana | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid, isozyme dgk-1 regulates diacylglycerol signalling required for acetylcholine release | Caenorhabditis elegans | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
additional information | complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | Mammalia | ? | - |
? | |
additional information | complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | Drosophila melanogaster | ? | - |
? | |
additional information | complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | Arabidopsis thaliana | ? | - |
? | |
additional information | complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | Caenorhabditis elegans | ? | - |
? | |
additional information | the isozyme zeta interacts with phosphoinositol phosphate 5-kinase activating it via phosphatidic acid, isozyme theta associates with RhoA, complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structure-function relationships of isozyme domain motifs, e.g. the C1 domain, the EF hand, and the pleckstrin homology, structural motifs and their organization, mammalian isozymes require other domain in addition to the catalytic domain for activity, overview | Mammalia |
More | structure-function relationships of isozyme domain motifs, e.g. the C1 domain, the EF hand, and the pleckstrin homology, structural motifs and their organization, mammalian isozymes require other domain in addition to the catalytic domain for activity, overview | Homo sapiens |
More | structure-function relationships of isozyme domain motifs, overview | Drosophila melanogaster |
More | structure-function relationships of isozyme domain motifs, overview | Arabidopsis thaliana |
More | structure-function relationships of isozyme domain motifs, overview | Caenorhabditis elegans |
Synonyms | Comment | Organism |
---|---|---|
DGK | - |
Drosophila melanogaster |
DGK | - |
Mammalia |
DGK | - |
Homo sapiens |
DGK | - |
Arabidopsis thaliana |
DGK | - |
Caenorhabditis elegans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Arabidopsis thaliana | |
ATP | - |
Caenorhabditis elegans | |
ATP | the binding sequence contains the GXGXXG motif essential for activity | Drosophila melanogaster | |
ATP | the binding sequence contains the GXGXXG motif essential for activity | Mammalia | |
ATP | the binding sequence contains the GXGXXG motif essential for activity | Homo sapiens |